|
KMID : 0376219930300020083
|
|
Chonnam Medical Journal
1993 Volume.30 No. 2 p.83 ~ p.92
|
|
|
6-Ketoprostaglandin F1a and thromboxane B2 concentrations of maternal blood in pregnancy induced hypertension
|
|
|
|
|
Abstract
|
|
|
Pathogenesis of pregnancy-induced hypertension is still controversial. The purpose of this study is to investigate pathophysiologic correlation between prostanoid concentration in maternal blood and pregnancy-induced hypertension. This study was
performed on 47 pregnancy patients associated with pregnancy-induced hypertension and 17 normal pregnant women seen in Chonnam University Hospital in KwangJu.
@ES In this study, the blood concentrations of 6-ketoprostaglandin F1αand thromboxane B2 were masured by radioimmunoassay.
@EN 1. The mean maternal blood concentration of 6-ketoprostglandin F1α in pregnancy-induced hypertension group was 444-42pg/ml, which was not significantly different from the concentration of normotensive group(452±42pg/ml, which was not
significantly
different from the concentration of normotensive group(452±54pg/ml).
2. The mean maternal blood concentration of thromboxane B2 in pregnancy-induced hypertension group was 560±40pg/ml, which was significantly higher than the concentration of normotensive group(345±31pg/ml) (P<0.05). But there was no difference
between
mild group and severe group.
3. There was no significant difference in thromboxane B2 to 6-keto prostaglandin F1 ratio between pregnancy-induced hypertension group(1.91±0.22) and normotensive group(1.14±0.26) .
The ratio also was not different between mild and severe pregnancy-induced hypertension.
These result suggest that the changes in the serum levels of prostaglandins are not the cause but the result of pregnancy-induced hypertension.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|